Miles Morales, an African-American and Puerto Rican teenager, lives in Brooklyn and struggles to fit in at his new middle school in Manhattan. But Miles’ life gets complicated when he gets bitten by a radioactive spider and discovers he has superpowers: he can now poison his opponents, he can camouflage himself, he can literally stick to walls and ceilings, his hearing is multiplied … At the same time, the most formidable criminal mastermind in the city, the Kingpin, has developed a nuclear particle gas pedal capable of opening a portal to other universes. His intention will bring several other versions of Spider-Man into Miles’ world, including an older Peter Parker, Spider-Gwen, Spider-Man Noir, Spider-Cochon and Peni Parker, from a Japanese cartoon.